A new way to fight antibiotic-resistant bacteria
Media: Cinema 4D (Arnold rendering), Adobe Illustrator, Adobe Photoshop, UCSF Chimera, UniProt
Client: Professor Derek Ng
Audience: Students, the public audiences who are interested in science
Outcomes: Creating a mock 2-page (molecular visualization) illustration spread for Scientific American (11 x 17"). This illustration explains the structure-function relationship of a biomolecular phenomenon.
This visualization depicts a novel therapeutic strategy to treat the bacterial infection as well as to prevent antibiotic resistance. The major goals were to show the steps of bacteria type three secretion system (T3SS) assembly, the mechanism of length sensing ruler proteins in controlling T3SS growth, and a potential method of antibiotic resistance prevention.
These major proteins sub-parts are obtained from PDB protein data bank. All the PDB files of protein subunits were first brought into the Chimera for cleaning and then exported as the ePMV Cin4d files. The cell membrane was directly created in Cin4d. I also used visual metaphors for the ruler proteins P & U, bacterial translocon, early and late substrates.